赵亮|南方医院关节与骨病外科

科研工作

长期从事骨与软骨再生医学方向研究工作，主要研究领域包括：
（1）以生物活化技术开发构建临床可应用的新型骨与软骨生物复合修复材料。
（2）利用新型复合生物材料及多种干细胞和生物因子促进骨骼组织再生（实验室，动物模型及前期临床应用）。
（3）骨与软骨再生的分子机制。
（4）干细胞在骨及软骨再生中的应用。

获得包括3项国家自然基金在内的省级以上项目资助15项。入选“广州市首届珠江科技新星计划”，“南方医科大学国家杰出青年培养计划”和“南方医科大学南方医院国家杰出青年培养计划”。主持1项“广东省创新强校支持项目”，1项“广东省高校千百十工程人才培养计划”。发表论文53篇（SCI文章33篇），总影响因子107.213，总引用次数490次（google scholar检索数据）。1篇通讯作者文章被选为Biomedical Materials Highlights of 2016 collection(IF:3.361)，通讯作者1篇Bone Research (IF:9.326)，Acta Biomaterialia (IF:6.025)，1篇Dental Material (IF: 4.16)，2篇J Tissue Engineering and Regenerative Medicine (IF: 4.71)，1篇Tissue Eng Part A，2篇Materials Science and Engineering(IF:3.420)等，第一作者3篇Biomaterials(IF:8.557)，1篇Tissue Eng Part A(IF:4.697)，1篇J. Tissue Eng Regen Med (IF: 4.71)。参编4部专著（其中1部英文），2项中国发明专利授权，受理4项。

发表论文 (按发表时间倒序)

1. Yang Xia, Jianfei Sun, Zhao Liang, Feimin Zhang, Xing-Jie Liang, Yu Guo, Michael D. Weir, Mark A. Reynolds, Ning Gu, Hockin H. K. Xu. Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration. Biomaterials . (Accepted August. 2018)（IF:8.806）
2. 宋兵, 廖哲霆, 邓仲豪, 吴德胜, 冯舒皓, 赵亮（通讯作者）.磷酸钙/壳聚糖/小分子腺苷复合材料修复大鼠颅骨极限骨缺损.南方医科大学学报, 2018, 16(3): 716.
3. 廖哲霆，邢祯全，陈宇璠，邓仲豪，吴德胜，赵亮（通讯作者）.关节腔注射抗坏血酸/氯化铁可延缓骨性关节炎大鼠软骨退变. 南方医科大学学报, 2018, 38(1): 62-68.
4. Wei Qin, Qi-Ting Huang, Michael D. Weir, Zhi Song,Ashraf F. Fouad, Zheng-Mei Lin, Liang Zhao(co-corresponding author), Hockin H. K. Xu. Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling. Stem Cells International. (accepted,July 2017) (IF:3.54)
5. Ping Wang, Lin Wang, Chongyun Bao, Qianming Chen, Michael D. Weir, Laurence C. Chow4, Liang Zhao(co-corresponding author), Xuedong Zhou, Hockin H. K. Xu, Mark A. Reynolds. A new generation of calcium phosphate cement constructs with stem cells and biologics for bone tissue engineering. Bone Research (Invited review article, 2017) (IF:9.326)
6. Chi Zhang, Kevin Hu, Xian Liu, Mark A. Reynolds,Chongyun Bao, Ping Wang, Liang Zhao(co-corresponding author), Hockin H. K. Xu. Novel hiPSC-based tri-culture for pre-vascularization of calcium phosphate scaffold to enhance bone and vessel formation. Materials Science & Engineering C. 2017 Oct 1;79:296-304 (IF:3.420)
7. Gengtao Qiu, Ping Wang, Jinyu Sun, Yang Song, Guangjun Li, Hockin H. K. Xu, Liang Zhao(co-corresponding author). Bone regeneration in minipigs via calcium phosphate cement scaffold delivering autologous BMSCs and platelet-rich plasma. J Tissue Engineering and Regenerative Medicine. 2017.18. doi: 10.1002/term.2416. [Epub ahead of print] (IF:4.71)
8. Liu X, Chen W, Zhang C, Thein-Han W, Hu K, Reynolds MA, Bao C, Wang P, Liang Zhao(co-corresponding author), Xu HHK. Co-Seeding Human Endothelial Cells with Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on Calcium Phosphate Scaffold Enhances Osteogenesis and Vascularization in Rats. Tissue engineering Part A. 2017 Jun;23(11-12):546-555. (IF:3.852)
9. Wenchuan Chen, Xian Liu, Qianmin Chen, Chongyun Bao, Zhao Liang(co-corresponding author), Zhimin Zhu, Hockin H.K. Xu. Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell coculture with hBMSCs, hUCMSCs, hiPSC-MSCs and hESC-MSCs. J Tissue Engineering and Regenerative Medicine.2017 Jan 18. doi: 10.1002/term.2395. [Epub ahead of print] (IF:4.71)
10. 黄志会,宋兵,陈宇璠,廖哲霆,赵亮（通讯作者）.抗坏血酸/PCL生物材料修复新西兰白兔软骨缺损的实验研究. 南方医科大学学报, 2017,37（5）：607-613
11. 宋兵，廖哲霆，陈宇璠，赵亮（通讯作者）.新型蜂巢样聚己内酯-硅酸钙复合晶体材料修复颅骨极限骨缺损. 中国组织工程研究杂志, 2017，21(18):2852-2857
12. Lin Wang, Chi Zhang, Chunyan Li , Michael D. Weir, Ping Wang, Mark A. Reynolds, Zhao Liang(co-corresponding author), Hockin H.K. Xu. Injectable calciumphosphate with hydrogel fibers encapsulating induced pluripotent, dental pulp and bone marrow stem cells for bone repair. Materials Science and Engineering C 2016.69: 1125–1136. (IF:3.420)
13. Lin Wang, Xianju Xie, Michael D. Weir, Ashraf F. Fouad, Zhao Liang(co-corresponding author), Hockin H. K. Xu. Effect of bioactive dental adhesive on periodontal and endodontic pathogens. Journal of Materials Science: Materials in Medicine. 2016.27(11):168. (IF:2.587) （引用次数：2）
14. Gengtao Qiu, Ping Wang, Guangjun Li,Zhanjun Shi, Michael D. Weir,Jinyu Sun, Yang Song, Jixing Wang,Huakun H. Xu, Zhao Liang(corresponding author).Minipig-BMSCs combined with a self-setting calcium phosphate paste for bone tissue engineering. Mol Cell Biochem. 2016.58(11):748-756. (IF:1.752)
15. Wang Lin, Wang Ping, Weir Michael, Reynolds Mark, Zhao Liang(co-corresponding author), Xu Hockin. Hydrogel fibers encapsulating hiPSC-MSCs, hESC-MSCs and hUCMSCs in injectable calcium phosphate scaffold for bone tissue engineering. Biomedical Materials. 2016.11(6):065008, Biomedical Materials Highlights of 2016 collection
16. Ping Wang, Yang Song, Michael D. Weir, Jinyu Sun, Zhao Liang(co-corresponding author), Carl G. Simon, Hockin Xu. A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering. Dental Materials. 2016.32(2):252-63.
17. 何瑞轩，肖建斌，宋兵，黄志会，赵亮（通讯作者）. 磷酸三钙复合骨形态发生蛋白-2/血小板衍生生长因子-BB修复SD大鼠颅骨标准骨缺损. 南方医科大学学报, 2016, 36(3): 345-350.
18. Wang Ping, Liu Xian, Zhao Liang(co-corresponding author), Michael Weir, Sun Jirun, Chen Wenchuan, Man Yi, Xu Huakun*. Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomaterialia. 2015.18:236-48.
19. Shi Zhe, Zhao Liang(co-first and co-corresponding author), Qiu Gengtao, He Ruixuan, Michael S. Detamore. The effect of extended passaging on the phenotype and osteogenic potential of human umbilical cord mesenchymal stem cells. Mol Cell Biochem. 2015.401:155–164. (IF:2.393) （引用次数：8）
20. 赵亮，史哲，吴宣平，王健，肖军，史占军. 系统性红斑狼疮合并股骨头坏死全髋关节置换术的围手术期治疗.中华关节外科杂志，2015.9：463-467.
21. 赵亮，闫广华，瞿东滨，赵卫东，史占军，张美超. 腰椎间盘退变对软骨终板生物力学特性影响的有限元分析.中国临床解剖学杂志，2015.33：455-460.
22. Wang Ping, Zhao Liang(co-corresponding author), Liu Jason, Michael D Weir, Xuedong Zhou, Xu Huakun. Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells. Bone Research. 2014.2:1-13. (IF: 3.549) （引用次数：82）
23. Wang Ping, Zhao Liang, Chen Wen, Liu Xin, M.D. Weir, Xu Huakun. Stem Cells and Calcium Phosphate Cement Scaffolds for Bone Regeneration. J Dent Res. 2014.93(7):618-625.
24. Dormer N, Singh M, Zhao Liang, Detamore MS. Osteochondral interface regeneration of the rabbit knee with macroscopic gradients of bioactive signals. Journal of Biomedical Materials Research: Part A. 2012.100(1):162-70.
25. 赵亮、Hockin Xu、王健、史占军. 磷酸钙骨水泥复合物/脐带间充质干细胞凝胶构建组织工程骨，中华关节外科杂志(电子版)， 2012.022:51-259.
26. Zhao Liang, Tang MH, Weir MD. Detamore MS, Xu Huakun. Effects of Osteogenic Media and BMP-2 Delivery on Umbilical Cord Stem Cells Encapsulated in Injectable Calcium Phosphate Scaffold. Tissue engineering Part A 2011.17:969-979. (IF:4.697) （引用次数：40）
27. Wang Limin, Zhao Liang(co-first author), Detamore MS. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J Tissue Eng Regen Med., 2011. 5(9):712-721.
28. Zhao Liang, Weir MD, Xu Huakun. An injectable calcium phosphate-alginate hydrogel-umbilical cord mesenchymal stem cell paste for bone tissue engineering. Biomaterials. 2010.31(14): 6502-10. (IF:8.557)（引用次数：169）
29. Zhao Liang, Weir MD, Xu Huakun. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. Biomaterials. 2010. 31(14):3848-57. (IF:8.557) （引用次数：82）
30. Zhao Liang, Burguera EF, Xu Huakun, Amin N, Ryou H, Arola DD. Fatigue and human umbilical cord stem cell seeding characteristics of calcium phosphate-chitosan-biodegradable fiber scaffolds. Biomaterials. 2010.31(5):840-7. (IF:8.557) （引用次数：76）
31. Xu Huakun, Zhao Liang, Detamore MS, Takagi S, Chow LC. Umbilical Cord Stem Cell Seeding on Fast-Resorbable Calcium Phosphate Bone Cement. Tissue Eng Part A. 2010.16(9):2743-2753.
32. Xu Huakun, Zhao Liang, Weir MD. Stem cell-calcium phosphate constructs for bone engineering. J Dent Res, 2010.89:1482-1488.
33. Zhao Liang, Detamore MS. Chondrogenic Differentiation of Stem Cells in Human Umbilical Cord Stroma with PGA and PLLA Scaffolds. J. Biomedical Science and Engineering, 2010.3:1041-1049.
34. Qu Dongbin, Zhao Liang, Jin Dadi. Effect of prosthetic nucleus pulposus replacement on stress distributions of lumbar disc endplate. Zhonghua Wai Ke Za Zhi. 2008;45:354-356.
35. 唐恒涛, 赵亮, 蒋辉等. 腰椎人工髓核假体置换后并发症及疗效评估. 中国组织工程研究与临床康复, 2008,12:2437-2441.
36. 瞿东滨，赵亮，金大地等. 腰椎间盘人工髓核植入对软骨终板应力分布的影响. 中华外科杂志，2008;45:354-356.
37. 赵亮，瞿东滨，金大地等．腰椎间盘人工髓核置换术后手术节段活动度和椎间隙高度变化的观察.中国脊柱脊髓杂志，2007,3:169-172.
38. 赵亮，瞿东滨，金大地等．腰椎间盘人工髓核置换术并发症原因分析及预防策略(附4年随访报告).中国矫形外科杂志，2007,5:331-333.
39. 金大地，赵亮，瞿东滨等．腰椎间盘人工髓核置换术后中期疗效分析.中华骨科杂志，2007,5:326-330.
40. 赵亮，瞿东滨，金大地等．人工髓核置换术治疗腰椎间盘突出症临床疗效分析.中国组织工程与临床康复杂志，2007;11:3127-3130.
41. 朱爱剑, 蔡启文, 赵亮等. 腰椎间盘人工髓核置换术后翻修一例. 中华外科杂志，2004; 42:765.
42. Jin Dadi, Qu Dongbin, Zhao Liang. Prosthetic disc nucleus replacement for lumbar disc herniation preliminary report with six month follow-up. Journal of spinal disorder & techniques 2003; 8:331-337.
43. 赵亮，瞿东滨，金大地. 正常人腰椎间盘的MRI测量及其临床意义.中国脊柱脊髓杂志,2003,13（4）：241－243.
44. 赵亮，瞿东滨，金大地等．枢椎棘突纤维组织细胞瘤一例报告. 中华骨科杂志，2003;23: 701.
45. 金大地，瞿东滨，赵亮等. 人工髓核假体置换术治疗腰椎间盘突出症的初步报告.中华骨科杂志，2003.23（5）:283-286.
46. 金大地，瞿东滨，赵亮等.腰椎间盘人工髄核置换术.中国矫形外科杂志,2002,10(11):1085-1087.0(11):1085-1087.

会议发言

1. Zhao Liang, Yang Dashan, Ren Pengfei, Shi Zhanjun. IASSIST navigation for total knee replacement. The 11th COA, Beijing, 2016.
2. Huang Zhihui, Chen Yufan, Liao Zheting, Zhao Liang(corresponding author). Cartilage-Healing Capicity of PCL/Ascorbic Acid Scafford in Articular Cartilage Defects In a Rabbit Model. The 4th Asian Cartilage repair society congress, 2016
3. Gengtao Qiu, Zhanjun Shi, Zhao Liang(co-corresponding author). Biofunctionalized calcium phosphate cement with human umbilical cord mesenchymal stem cells for bone tissue engineering. Guangdong Orthopaedic Annual meeting,2013
4. Zhao Liang, Limin Wang, Michael S. Detamore. A Sandwich Approach for Osteochondral Tissue Engineering with Human Umbilical Cord Mesenchymal Stem Cells. The 7th COA, Beijing, 2012.
5. Zhao Liang, Detamore MS. Co-Culture to Mediate Chondrogenic and Osteogenic Differentiation of Human Umbilical Cord Mesenchymal Stromal Cells. The 6th COA, Beijing, 2011.12.01-04.
6. Zhao Liang, Weir M, Xu HHK. Human umbilical cord stem cell encapsulation in calcium phosphate scaffolds for bone engineering. The 5th COA, Chengdu, 2010.11.11-14, Oral presentation.
7. Zhao Liang, Weir M, Xu HHK. Osteogenic differentiation and mineralization via umbilical-cord stem cell/calcium phosphate constructs. International Association for Dental Research, Washington D.C. (2010).
8. Xu HHK, Zhao Liang, Detamore MS. Umbilical-cord stem cell seeding on fast-dissolution calcium phosphate bone cements. International Association for Dental Research, Washington D.C. (2010).
9. Zhao Liang, Detamore MS. Phenotypic analysis of human umbilical cord mesenchymal stromal cells induced by prolonged passaging culture, Biomedical Engineering Society, Pittsburgh, PA (2009).
10. Zhao Liang, Detamore MS. Comparative analysis of collagenase digestion as method to isolate Mesenchymal-like cells from human umbilical cord. Society for Physical Regulation in Biology and Medicine, Hawaii, HI (2009).
11. Zhao Liang, Detamore MS. Co-culture of human umbilical cord mesenchymal stromal cells with primary chondrocytes and osteoblasts promote chondrogenic and osteogenic differentiation. Society for Physical Regulation in Biology and Medicine, Hawaii, HI (2009).
12. Wang Limin, Zhao Liang, Detamore MS. Human Umbilical Cord Mesenchymal Stromal Cells-Based Tissue Engineering Approach for Osteochondral Construct. Society for Physical Regulation in Biology and Medicine, Hawaii, HI (2009).
13. Weir MD, Zhao Liang, Xu HHK. Human mesenchymal stem cell delivery via calcium phosphate scaffolds for bone tissue engineering. Oral presentation, World Stem Cell Summit, Baltimore, MD (2009).
14. Dormer N, Singh M, Zhao Liang. Osteochondral Tissue Engineering Using Macroscopic Gradients of Bioactive Signals, Biomedical Engineering Society, Pittsburgh, PA (2009).
15. Lazebnik M, Glatt P, Zhao Liang, Berkland C, Detamore MS. A biomimetic approach to the intervertebral disc regeneration. Orthopaedic Research Society, Las Vegas, NV (2009).
16. Zhao Liang, Wang Limin, Detamore MS. Chondrogenic differentiation of human umbilical cord mesenchymal stromal cells. Biomedical Engineering Society, St Louis, MO (2008).
17. Lazebnik M, Singh M, Zhao Liang, Berkland C, Detamore MS. Novel hybrid scaffolds for the intervertebral disc tissue engineering, Biomedical Engineering Society, St. Louis, MO (2008).
18. Zhao Liang, Qu Dongbin, Jin Dadi. Prosthetic Disc Nucleus (PDN) Replacement for Lumbar Disc Herniation -Report with Four Years Follow-up. North American Spine Society, Toronto, Canada (2008).

参编专著

1. 金大地，瞿东滨，赵亮. 人工髓核置换术. 见：杨述华主编，实用脊柱外科学，北京：人民军医出版社，2004.844.
2. 赵亮，瞿东滨，金大地. 下腰痛的临床疗效评分, 人工髓核假体置换术. 见：金大地，瞿东滨，Charles D.Ray 主编，脊柱椎间关节成形术，北京：科学技术文献出版社，2004，56.
3. 金大地，瞿东滨，赵亮. 人工髓核置换术. 见：候树勋主编，脊椎外科学，北京：人民军医出版社，2005, 482.
4. Hockin H. K. Xu, Michael D. Weir, Zhao Liang, Jennifer L. Moreau, Dwayne D. Arola1, Carl G. Simon. Nano-Apatitic Composite Scaffolds for Stem Cell Delivery and Bone Tissue Engineering. Book chapter in Nanotechnology for Dental Applications (2009).

课题资助

1. 广东省自然科学基金重点项目资助，2018B030311041，高效能骨诱导再生材料的骨修复作用及分子机制，50万，主持。
2. 国家自然基金（面上项目），31771051，可持续高效募集宿主细胞的新型骨生物复合材料在骨修复中的作用及其分子机制，2018.1-2021.12，58万，主持
3. 国家自然科学基金（海外合作），31328008，基于磷酸钙复合物新型骨生物材料构建及其对干细胞成骨分化影响的机制研究，2014.1-2015.12，20万，主持
4. 国家自然科学基金（青年项目），31100695，CPC与hUCMSCs水凝胶微囊构建可注射组织工程骨及其转归机制，2012.1-2014.12，23万，主持
5. 广州市科技项目生物医药与健康专题，新型智能骨生物材料关键技术研发，2017-2019，200万，主持
6. 广东省自然科学基金，2014A030313275，BMP抗体介导的iPS细胞成骨分化调控及其作用的机制研究，2015.1-2018.1，10万，主持
7. 广东省自然科学基金，s2013010014253，生物功能化CPC支架复合自体干细胞体系构建及在大段骨缺损修复中作用，2015.1-2016.12，5万，主持
8. 广东省科技计划项目，2012B010200024，基于磷酸钙复合生物材料的骨组织研发，2012.12-2015.11，8万，主持
9. 教育部出国留学人员启动项目，脐带间充质干细胞梯度释放支架构建组织工程骨软骨及修复骨软骨缺损的应用，2014.1-2015.12，3万，主持
10. 教育部青年教师基金，20114433120003，CPC与hUCMSCs水凝胶微囊构建可注射组织工程骨及其转归机制，2012.1-2014.12，4万，主持
11. 广东省创新强校特色创新类项目，2014KTSCX047，BMP抗体接到的IPS细胞成骨分化调控及在骨缺损修复中作用的实验研究，2015.6-2017.5，4万，主持
12. 广州市珠江科技新星，2012027，基于可注射性支架材料的骨组织再生与构建研究，2012.7-2015.6，30万，主持
13. 广东省医学科研基金，B2011196，一种可注射强化型磷酸钙/干细胞微囊组织工程骨的构建和应用研究，2011.7-2013.6，2万，主持
14. 广州出国留学人员启动项目，脐带间充质干细胞梯度释放支架构建组织工程骨软骨及修复骨软骨缺损的应用，2011.1-2013.12，3万，主持
15. 南方医科大学国家杰出青年培养对象，BMP家族及其抗体对MSCs移行归巢的调控作用及其机制，2014.10-2017.09，90万，主持
16. 南方医科大学南方医院国家杰出青年培养对象，基于可注射性支架材料的骨组织再生与构建的重要基础研究，2012.6-2015.5，30万，主持
17. 南方医科大学南方医院院级教育课题，11NJ-MS02，骨科物理检查双语视听教材制作，2011.12-2013.11，1万，主持